Congenital Malformations among the Offspring of Danish Survivors of Childhood Cancer and their Siblings – Interim Results
نویسندگان
چکیده
Survival is now the norm for children treated with radiotherapy and chemotherapy for childhood cancers. These children are now living to have children of their own. A Danish study of adverse health outcomes in the offspring of childhood cancer survivors and the offspring of the cancer survivor’s siblings is ongoing. The cumulative probability of congenital malformation is non significantly higher amongst the offspring of cancer survivors than amongst the offspring of cancer survivor’s siblings; and non significantly higher amongst the offspring of cancer survivors who received radiotherapy treatment compared with those who did not. Future analyses will incorporate radiation dose to the uterus and gonads of cancer survivors. To date, studies of childhood cancer survivors’ offspring have not indicated an excess of congenital malformation.
منابع مشابه
Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study.
These studies were undertaken to determine the effect, if any, of treatment for cancer diagnosed during childhood or adolescence on ovarian function and reproductive outcomes. We reviewed the frequency of acute ovarian failure, premature menopause, live birth, stillbirth, spontaneous and therapeutic abortion and birth defects in the participants in the Childhood Cancer Survivor Study (CCSS). Ac...
متن کاملPrevalence of Obesity, Dyslipidemia, and Insulin Resistance in Childhood Cancer Survivors
Background: With the increased survival rates following the treatment of childhood cancer, it becomes equally important that the need for evidence based surveillance of long term effects of cancer therapy is addressed. This includes the risk of development of metabolic syndrome features like obesity, altered lipid and sugar profile, which was attempted in the present study. Materials and Metho...
متن کاملNeonatal outcomes of Offspring Conceived through in Vitro Fertilization
There has been a dramatic rise in the use of Assisted Reproductive Technologies (ART), including In Vitro Fertilization (IVF) throughout the world over the past three decades. Because they represent >1% of the birth cohorts in many developed countries, much attention is being paid to the health and well-being of ART children. Children born after assisted reproductive techniques (ART) have an in...
متن کاملParenthood in survivors after adulthood cancer and perinatal health in their offspring: a preliminary report.
Cancer survivors may fear infertility, obstetric problems, and genetic alterations in their offspring. After linkage of three registries the probability of post-treatment parenthood and the risk of obstetric and perinatal problems were estimated in cancer survivors compared to individuals without a cancer diagnosis. A total of 1531 of 13,817 patients had 2307 children after one parent's cancer ...
متن کاملIncreased risk of cancer among siblings of long-term childhood cancer survivors: a report from the childhood cancer survivor study.
We determined risk of cancer among first-degree relatives of 5-year survivors of childhood leukemia, lymphoma, central nervous system tumors, sarcomas, Wilms' tumor, and neuroblastoma. Subjects were 13,703 participants in the Childhood Cancer Survivor Study. Family history was collected on 56,759 first-degree relatives using a self-reported questionnaire. Incidence was compared with age- and se...
متن کامل